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In a second food effect study of similar design, two 400 mg skelaxin tablets (800 mg) were administered to healthy volunteers (n59, 37 males, 22 females), ranging in age from 18-50 years (mean age 25. Metaxalone (generic skelaxin) and other musculoskeletal conditions drugs at cvs, walgreens, and other pharmacies. The single-dose pharmacokinetic parameters of metaxalone in two groups of healthy volunteers are shown in table 1.

Similar food effect results were observed in the above study when one skelaxin 800 mg tablet was administered in place of two skelaxin 400 mg tablets. Safe use of metaxalone has not been established with regard to possible adverse effects upon fetal development. Forte dsc, slug parafon-forte-dsc, display robaxin, slug robaxin, display skelaxin, slug skelaxin, display soma, slug soma, display soma compound, slug soma-compound, display soma compound with codeine, slug soma-compound-with-codeine, display spinraza, slug spinraza, display valium, slug valium, primarytitleannotated metaxalone, warningscount 0, haswhatis true, equivalentdrugs skelaxin forms tablet dosagesort 800mg, dosages 800mg quantities 10, 20, 30, 60, 90, drugid 5041, name 800mg, defaultquantity 90, singular tablet, plural tablets, display tablet, defaultdosage 800mg, generic false, defaultdayssupply 30, dayssupplies 30, 90, formsort tablet, defaultform tablet, display skelaxin, slug skelaxin, metaxalone forms tablet dosagesort 400mg, 800mg, dosages 400mg quantities 15, 21, 30, 60, 90, drugid 40892, name 400mg, defaultquantity 30, 800mg quantities 15, 21, 30, 60, 90, drugid 5042, name 800mg, defaultquantity 30, singular tablet, plural tablets, display tablet, defaultdosage 800mg, generic true, defaultdayssupply 30, dayssupplies 30, 90, formsort tablet, defaultform tablet, display metaxalone, slug metaxalone, secondarytitleannotated generic skelaxin, notices , sponsoredlisting null, secondarytitle generic skelaxin, conditions display musculoskeletal conditions, slug musculoskeletal-conditions, isdruginfotest false, metatitle pricepageotc compare metaxalone prices - goodrx, sideeffectspage metaxalone side effects, information and pricing - goodrx, medicareseopage metaxalone medicare coverage and co-pay details - goodrx, pricepage metaxalone prices and metaxalone coupons - goodrx, infopage what is metaxalone? - goodrx, imagespage metaxalone images and labels - goodrx, latestnewspage latest news and savings tips for metaxalone by doctors and pharmacists - goodrx, savingspage metaxalone - savings tips - goodrx, headertitle metaxalone, formslug tablet, form tablet, warnings , inlines , secondarydrugs manufacturer brand, name skelaxin, slug skelaxin, dayssupply 30, isdefault true, hassideeffects true, labeloverride null, slug metaxalone, manufacturer generic, retentionscience name 88985d2b1c7d33acdb791f24c6bc57afb390699b50033340d8ef23be75df1e89, latestnewscount 6, name metaxalone, drugdescription metaxalone is a muscle relaxer.

The mode of action of this drug has not been clearly identified, but may be related to its properties. Compared to fasted conditions, the presence of a high fat meal at the time of drug administration increased c by 193. There was an error detecting your location, please manually enter your location below goodrx finds the lowest prices for prescriptions at pharmacies near you.

Stop using metaxalone and call your doctor at once if you have any of these serious side effects , and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. Each tablet contains 800 mg metaxalone and the following inactive ingredients alginic acid, ammonium hives difficulty breathing swelling of your face, lips, tongue, or throat. Skelaxin may impair mental andor physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle, especially when used with alcohol or other cns depressants.

Therefore, metaxalone tablets should not be used in women who are or may become pregnant and particularly during early pregnancy unless, in the judgement of the physician, the potential benefits outweigh the possible hazards. The structural formula is metaxalone is a white to almost white, odorless crystalline powder freely soluble in chloroform, soluble in methanol and in 96 ethanol, but practically insoluble in ether or water. Save up to 80 instantly!, sideeffectspage learn about side effects and possible interactions when taking metaxalone (generic skelaxin), medicareseopage medicare coverage and pricing details for metaxalone.

The impact of hepatic and renal disease on the pharmacokinetics of metaxalone has not been determined. Deaths by deliberate or accidental overdose have occurred with metaxalone, particularly in combination with , and have been reported with this class of drug in combination with alcohol. Metaxalone does not significantly inhibit major cyp enzymes such as cyp1a2, cyp2a6, cyp2b6, cyp2c8, cyp2c9, cyp2c19, cyp2d6, cyp2e1, and cyp3a4. Due to the potential for ss, caution is advised when metaxalone is co-administered with drugs that may affect the serotonergic you are encouraged to report negative side effects of prescription drugs to the fda. Goodrx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site.


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    The increase in metaxalone exposure coinciding with a reduction in half-life may be attributed to more complete absorption of metaxalone in the presence of a high fat meal (figure 1). The results were analyzed separately, as well as in combination with the results from three other studies. Stop using metaxalone and call your doctor at once if you have any of these serious side effects , and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions. Deaths by deliberate or accidental overdose have occurred with metaxalone, particularly in combination with , and have been reported with this class of drug in combination with alcohol. This information is for informational purposes only and is not meant to be a substitute for professional medical advice, diagnosis or treatment.

    There was an error detecting your location, please manually enter your location below goodrx finds the lowest prices for prescriptions at pharmacies near you. Figure 1 mean (sd) concentrations of metaxalone following an 800mg dose under fasted and fed conditions although plasma protein binding and absolute bioavailability of metaxalone are not known, the apparent volume of distribution (vf 800 l) and lipophilicity (log p 2. Similar food effect results were observed in the above study when one skelaxin 800 mg tablet was administered in place of two skelaxin 400 mg tablets. The bioavailability of metaxalone was significantly higher in females compared to males as evidenced by cmax (2115 ngml versus 1335 ngml) and auc (17884 nghml versus 10328 nghml). The impact of hepatic and renal disease on the pharmacokinetics of metaxalone has not been determined.

    It is used to treat pain and stiffness in muscles caused by strains, sprains, or other injury. Each tablet contains 800 mg metaxalone and the following inactive ingredients alginic acid, ammonium hives difficulty breathing swelling of your face, lips, tongue, or throat. Available in bottles of 100 ( store at controlled room temperature, between 15c and 30c (59f and 86f). Using the combined data, the results indicate that the pharmacokinetics of metaxalone are significantly more affected by age under fasted conditions than under fed conditions, with bioavailability under fasted conditions increasing with age. The apparent volume of distribution of metaxalone was approximately 22 higher in males than in females, but not significantly different when adjusted for body weight. As a general rule, nursing should not be undertaken while a patient is on a drug since many drugs are excreted in human milk. Metaxalone does not significantly induce major cyp enzymes such as cyp1a2, cyp2b6, and cyp3a4 the effects of age on the pharmacokinetics of metaxalone were determined following single administration of two 400 mg tablets (800 mg) under fasted and fed conditions. Cyp1a2, cyp2d6, cyp2e1, and cyp3a4 and, to a lesser extent, cyp2c8, cyp2c9, and cyp2c19 appear to metabolize metaxalone. Peak plasma concentrations of metaxalone occur approximately 3 hours after a 400 mg oral dose under fasted conditions. Therefore, caution should be exercised with patients who take more than one of these cns depressants simultaneously.

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